ABSTRACT
JugLans regia is the main economic crop in China and an important medicinal plant, which have antibacterial, anti-oxidant, anti-tumor and hypoglycemic effects. It mainly contains a variety of active small molecule compounds such as polysaccharides, flavonoids, phenolic acids, esters, saponins and quinones.It can be used not only for the development of pharmaceuticals or functional foods, but also for its market demand in the food industry with good application base. It is a resource material with great development potential in walnuts. In this paper, the chemical composition and pharmacological effects of walnut were systematically combed, and on this basis, the industrial application and development path were analyzed to provide a basis for the development and utilization of walnut resources in China.
ABSTRACT
Objective: To investigate the diarylheptanoids from the flower of Juglans regia. Methods: The compounds were isolated and purified by various column chromatographies, and their structures were identified by physiochemical properties and spectroscopic data. And MTT assays were performed to detect the in vitro cytotoxicity of compounds. Results: A total of 11 diarylheptanoids were isolated from the EtOH extract of the flower of J. regia, which were identified as tsaokoarylone (1), rhoiptelol C (2), (3S,7S)-3,7-dihydroxy-1-(4-hydroxyphenyl)-7-(3-methoxy-4-hydroxyphenyl)-heptane (3), 3-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-7- (4-hydroxyphenyl) heptane (4), 1-(4-hydroxyphenyl)-7-(3-methoxy-4-hydroxyphenyl)-4-heptene-3-one (5), juglanin A (6), 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7-(20),15,17,18-hexane-10,16-diol (7), 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7-(20),15,17,18-hexane- 10-one (8), pterocarine (9), (8R)-32-methoxy-2-oxa-1(1,3),3(1,4)-dibenzenacyclodecaphane-16,8-diol (10), and juglanin B (11). Conclusion: Compounds 1-2, 4-5, and 7-8 are isolated from this genus for the first time. Compounds 1-11 are isolated from this plant for the first time, and compound 8 inhibited the proliferation of HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cancer cell lines in vitro, with IC50 values of 3.56, 2.26, 1.39, 2.62, and 1.18 μmol/L, respectively.
ABSTRACT
The aim of our study was to evaluate the gastro protective effect of aqueous extract of Juglans regia.L leaves in albino rats. Albino rats of wistar variety weighing 140-165gms were used in the experiment. The sexes were evenly divided into different treatment groups. The aqueous leaf extract of Juglans regia.L was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 500mg/kg body weight p.o. Histopathological assessment of rat stomach was carried out. A significant reduction (p<0.01) in ulcer index was seen in leaf extracts of Juglans regia.L treated rats of pylorus ligation, aspirin induced and ethanol induced gastric ulcer models. The gastro protective effect was further confirmed by histopathological examination of rat stomach. Thus the present study concludes the Juglans regia.L leaf extract having potential gastro protective effect in the three models tested.
ABSTRACT
The proximate composition of eleven walnut (Juglans regia L.) genotypes (28 ŞK 010, 28 ŞK 055, 28 ŞK 041, 28 ŞK 601, 28 ŞK 925, 28 ŞK 028, 28 ŞK 118, 28 ŞK 350, 28 ŞK 930, 28 ŞK 850, 28 ŞK 036) and three walnut cultivars (Şebin, Bilecik, Kaman 1) produced in Turkey were determined. The oil content of the samples ranged from 61.32 to 69.35%, corresponding to an energy value of approximately 710 kcal per 100 g of kernel. The protein content ranged from 10.58 to 18.19%, and the carbohydrate composition was between 9.05 and 18.92%. The ash content ranged from 1.53 to 1.99%, and the moisture content of the kernels was between 1.91 and 4.48% the oleic acid content of the oils ranged from 17.90 to 33.35% of the total fatty acids. The linoleic acid content ranged from 43.15 to 60.20%. The linolenic acid content ranged from 9.98 to 13.00%. The palmitic acid content was between 5.21 and 8.40%. Stearic acid ranged from 2.36 to 4.25%. Potassium was the major mineral in all the samples, ranging from 359.73 to 482.97 mg/100 g. Calcium was the next most abundant mineral, ranging from 109.45 to 335.97 mg/100 g, followed by magnesium, ranging from 126.01 to 165.15 mg/100 g.